2nd Annual Symposium of NYC Tri-I TRAC

Repost from the Weill Cornell WCM NYC TRAC page, found here. 

On November 25, we successfully organized the 2nd annual NYC Tri-I TRAC symposium at Weill Cornell Medicine in New York. This year’s event featured a diverse lineup of presentations, including proposals from current seed-grant recipients, updates from past investigators supported by NYC TRAC, and a guest speaker from SEATRAC, another TRAC based in Seattle. 

The first session was dedicated to presentations by the current seed-grant recipients. Below is the list of speakers and their presentation titles: 

  • Dr. Prabhat Ranjan Singh 
    "Examining the function of genes contributing to Mycobacterium tuberculosis survival during transmission at the stage of macrophage infection in a lung environment model" 

  • Dr. Vijay Soni 
    "Study of peptidoglycan salvage and recycling pathways and their role in the evolution of antimicrobial resistance in Mycobacterium tuberculosis" 

  • Dr. Valerie Vinette 
    "Identification of host TNF-α-dependent pathways involved in tuberculosis relapse" 

  • Dr. Ekaterina Vinogradova 
    "Characterization of Mycobacterium tuberculosis protein landscapes using advanced proteomic platforms" 

  • Dr. Jonah Kreniske 
    "HIV and the post-tuberculosis cardiopulmonary syndrome" 

The next speaker was Dr. Shuibing Chen, a Professor of Chemical Biology in Surgery at Weill Cornell Medical College. Supported by the TRAC grant as an investigator new to the TB field, Dr. Chen presented her work on “Human pluripotent stem cell (hPSC)-derived immune-lung organoids to study TB infection.” Her talk highlighted the potential of using hPSC-derived models to investigate the biological functions and molecular mechanisms in Mtb infection, in collaboration with Carl Nathan, the Developmental Core Director of NYC TRAC. 

We were also pleased to welcome Dr. Vishant Boradia, a Research Scientist III at Seattle Children's Research Institute. His presentation, titled “Unraveling the role of PE/PPE proteins in tuberculosis drug resistance,” focused on the function of PE/PPE proteins as outer membrane drug transporters and their potential contribution to Mtb drug susceptibility and resistance. 

In the final session of the symposium, researchers supported by the NYC TRAC seed grants shared their progress in successfully applying for NIH R01 grants. The speakers and their presentation titles are listed below: 

  • Dr. Kathryn Dupnik 
    "Impact of tuberculosis coinfection on HIV reservoirs" 

  • Dr. Alexandre Gouzy 
    "Reliable phenotypic detection of pyrazinamide-resistant tuberculosis" 

  • Dr. Christopher Brown 
    "Mfd-dependent mutagenesis and genetic diversification in Mycobacterium tuberculosis" 

  • Dr. Kohta Saito 
    "Metabolic regulation underlying subpopulation diversity in growth recovery phenotypes after antibiotic exposure in Mycobacterium tuberculosis" 

For more details about the seed-grant recipients and their research, please visit this page.

Picture: Global Health Center director Dr. Dan Fitzgerald gives a talk at the symposium

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